British Air Force Typhoon FGR4s have conducted a mission with France's air force in a coordinated attack targeting an hidden munitions depot in Syria employed by the IS group, as stated by the British defence ministry.
The location, located using reconnaissance, was assessed as storing arms and explosives, the announcement noted, and was positioned in mountainous terrain just above the historic site of Palmyra in central Syria.
"Our fighter planes utilized Paveway IV guided bombs to hit a number of entry passages down to the site... early reports are that the strike was effective," the ministry announced.
There was no indication of any harm to civilians in the operation late on Saturday and every plane involved made a safe return, the MoD added.
The British jets were assisted by a Voyager aerial refuelling aircraft.
The Islamic State group - alternatively referred to as the so-called Islamic State - imposed jihadist rule over parts of Syria and Iraq before its territorial defeat in 2019.
"This action demonstrates British leadership, and determination to stand shoulder to shoulder with allied nations, to eliminate any re-emergence of Daesh and their violent and radical beliefs in the Middle East," Britain's Defence Chief John Healey said.
RAF aircraft have carried out overwatch operations over Syria to "deter any attempted comeback" of Islamic State following its defeat at the battle of Baghuz in 2019, the ministry said.
"I want to thank every member of British forces who took part in this mission for their skill and their bravery," he added. "Including them were thousands of British personnel on duty over the festive period. This action, to remove dangerous terrorists who pose a risk to our safety, shows how British military are ready to step up, throughout the year, keeping Britain secure domestically and powerful internationally."
In December, the American forces executed what it termed a "major assault" targeting Islamic State objectives in Syria, following an attack claimed the lives of two US troops and a civilian linguist in Palmyra.
The U.N. says IS still maintains an estimated 5,000 to 7,000 fighters in both countries.